11.19.17

April Background

I created this new background for April! A reminder to all the great girls out there who are awesome human beings!

For a high quality foto, check out the link in my previous post!

20.1.18 // studygram: alimastudies

i don’t normally upload pictures of my homework because i don’t tend to spend a lot of effort or time on them as i know i won’t be using it again, but for this biology homework i thought i would do it nicely and use it for my future notes! i need to work on my handlettering oh dear god ahhh i used a crayola supertip for it

Gram staining

Mechanism of Fever

MORE MIXED MNEMONICS

18/1/18 - Recent virology notes! Ignore the headings, I bought some new brush pens and I’m still getting used to them..

Virus Classification

Yesterday’s notes featuring actual winter sunshine!!

Antimicrobial Agents  - Cell wall inhibitors

Based on mode of action • divided into families based on chemical structure

 Modes of action Interference with: 

cell wall synthesis 

protein synthesis 

nucleic acid synthesis 

plasma membrane integrity 

metabolic pathway 

Inhibitors of Bacterial Cell Wall (peptidoglycan) Synthesis 

The Beta-lactam Family 

The Glycopeptides 

Peptidoglycan is composed of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) repeat units, and amino acids.  Each NAM is linked to peptide chain and the peptide chains are cross-linked.

β-lactams 

Includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems.

class of broad-spectrum antibiotics containing a β-lactam ring

Bacterial transpeptidase enzymes are responsible for catalysing cross-linking of the peptide chains

β-lactam ring bind to these transpeptidases – this inhibits cross-linking between peptide chains and prevents synthesis of stable PG

Cell wall synthesis ceases and the bacterial cells eventually die due to osmotic instability or autolysis. 

Glycopeptides 

Polypeptide agents - basic structural elements amino acids 

Vancomycin: 

complexes with peptide portion of peptidoglycan’s precursor units 

vancomycin is a large hydrophilic molecule able to form hydrogen bonds with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

preventing PG transglycosylation reaction – PG precursor subunits (NAG-NAM+peptide) cannot be inserted into peptidoglycan matrix;

Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis

Uses:  serious Gram positive infections e.g. MRSA wound infection

Adverse effects:

damage to auditory nerve 

hearing loss (ototoxicity) 

“Red man/neck” syndrome - rash on face, neck, upper torso 

nov.21 | day 21 of @justjasminestudying‘s challenge

21. Show me some work/notes you’re most proud of

This picture was taken back when I was still in dental school and the subject was immunology. It was so complicated D: But at least I now know how to color code stuff lmao

song of the day : IU - Through the Night